Comparison between saliva stimulants and saliva substitutes in patients with symptoms related to dry mouth. A multi-centre study.
Identifieur interne : 000660 ( Main/Exploration ); précédent : 000659; suivant : 000661Comparison between saliva stimulants and saliva substitutes in patients with symptoms related to dry mouth. A multi-centre study.
Auteurs : M. Björnström [Suède] ; T. Axéll ; D. BirkhedSource :
- Swedish dental journal [ 0347-9994 ] ; 1990.
Descripteurs français
- KwdFr :
- Acide ascorbique (usage thérapeutique), Acide lactique (MeSH), Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Association médicamenteuse (MeSH), Carboxyméthylcellulose de sodium (usage thérapeutique), Débit sécrétoire (effets des médicaments et des substances chimiques), Femelle (MeSH), Glycérol (usage thérapeutique), Humains (MeSH), Lactates (usage thérapeutique), Nicotinamide (usage thérapeutique), Salive (effets des médicaments et des substances chimiques), Salive (effets des radiations), Salive artificielle (usage thérapeutique), Sorbitol (usage thérapeutique), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Xérostomie (physiopathologie), Xérostomie (thérapie), Xérostomie (étiologie).
- MESH :
- effets des médicaments et des substances chimiques : Débit sécrétoire, Salive.
- effets des radiations : Salive.
- physiopathologie : Xérostomie.
- thérapie : Xérostomie.
- usage thérapeutique : Acide ascorbique, Carboxyméthylcellulose de sodium, Glycérol, Lactates, Nicotinamide, Salive artificielle, Sorbitol.
- étiologie : Xérostomie.
- Acide lactique, Adolescent, Adulte, Adulte d'âge moyen, Association médicamenteuse, Femelle, Humains, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Ascorbic Acid (therapeutic use), Carboxymethylcellulose Sodium (therapeutic use), Drug Combinations (MeSH), Female (MeSH), Glycerol (therapeutic use), Humans (MeSH), Lactates (therapeutic use), Lactic Acid (MeSH), Middle Aged (MeSH), Niacinamide (therapeutic use), Saliva (drug effects), Saliva (radiation effects), Saliva, Artificial (therapeutic use), Secretory Rate (drug effects), Sorbitol (therapeutic use), Xerostomia (etiology), Xerostomia (physiopathology), Xerostomia (therapy).
- MESH :
- chemical , therapeutic use : Ascorbic Acid, Carboxymethylcellulose Sodium, Glycerol, Lactates, Niacinamide, Saliva, Artificial, Sorbitol.
- drug effects : Saliva, Secretory Rate.
- etiology : Xerostomia.
- physiopathology : Xerostomia.
- radiation effects : Saliva.
- therapy : Xerostomia.
- Adolescent, Adult, Aged, Aged, 80 and over, Drug Combinations, Female, Humans, Lactic Acid, Middle Aged.
Abstract
Five saliva stimulants (Salivin, V6, Mucidan, Ascoxal-T and Nicotinamide) and three saliva substitutes (Saliment, Salisynt and an ex témpore solution) were evaluated in 106 patients with a low salivay flow rate and a long history of dry mouth. The study was carried out as a multi-centre study in collaboration with ten different hospital dental clinics. The participants were interviewed about their complaints related to dry mouth. Each patient was then asked to use the eight saliva stimulants and substitutes for 14 days in a randomized order with one week intervals. After the 14-day-periods, the patients were interviewed about the effect of the various products by a dentist using a standardized questionnaire. Paraffin-stimulated whole saliva samples were collected after each test period. The most serious complaints among the patients were, besides dryness of the mouth, difficulty to talk and difficulty to swallow. The results showed that all eight tested saliva stimulants and substitutes relieved the symptoms of dry mouth to some extent. However, V6 chewing gum and Salivin lozenge were ranked as the two best products by the patients. No long-term effect was found with any of the eight products on the flow rate of paraffin-stimulated whole saliva.
PubMed: 2147787
Affiliations:
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The study was carried out as a multi-centre study in collaboration with ten different hospital dental clinics. The participants were interviewed about their complaints related to dry mouth. Each patient was then asked to use the eight saliva stimulants and substitutes for 14 days in a randomized order with one week intervals. After the 14-day-periods, the patients were interviewed about the effect of the various products by a dentist using a standardized questionnaire. Paraffin-stimulated whole saliva samples were collected after each test period. The most serious complaints among the patients were, besides dryness of the mouth, difficulty to talk and difficulty to swallow. The results showed that all eight tested saliva stimulants and substitutes relieved the symptoms of dry mouth to some extent. However, V6 chewing gum and Salivin lozenge were ranked as the two best products by the patients. No long-term effect was found with any of the eight products on the flow rate of paraffin-stimulated whole saliva.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">2147787</PMID><DateCompleted><Year>1991</Year><Month>01</Month><Day>18</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0347-9994</ISSN><JournalIssue CitedMedium="Print"><Volume>14</Volume><Issue>4</Issue><PubDate><Year>1990</Year></PubDate></JournalIssue><Title>Swedish dental journal</Title><ISOAbbreviation>Swed Dent J</ISOAbbreviation></Journal><ArticleTitle>Comparison between saliva stimulants and saliva substitutes in patients with symptoms related to dry mouth. A multi-centre study.</ArticleTitle><Pagination><MedlinePgn>153-61</MedlinePgn></Pagination><Abstract><AbstractText>Five saliva stimulants (Salivin, V6, Mucidan, Ascoxal-T and Nicotinamide) and three saliva substitutes (Saliment, Salisynt and an ex témpore solution) were evaluated in 106 patients with a low salivay flow rate and a long history of dry mouth. The study was carried out as a multi-centre study in collaboration with ten different hospital dental clinics. The participants were interviewed about their complaints related to dry mouth. Each patient was then asked to use the eight saliva stimulants and substitutes for 14 days in a randomized order with one week intervals. After the 14-day-periods, the patients were interviewed about the effect of the various products by a dentist using a standardized questionnaire. Paraffin-stimulated whole saliva samples were collected after each test period. The most serious complaints among the patients were, besides dryness of the mouth, difficulty to talk and difficulty to swallow. The results showed that all eight tested saliva stimulants and substitutes relieved the symptoms of dry mouth to some extent. However, V6 chewing gum and Salivin lozenge were ranked as the two best products by the patients. No long-term effect was found with any of the eight products on the flow rate of paraffin-stimulated whole saliva.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Björnström</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hospital Dental Clinic, Danderyd Hospital, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Axéll</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Birkhed</LastName><ForeName>D</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Sweden</Country><MedlineTA>Swed Dent J</MedlineTA><NlmUniqueID>7706129</NlmUniqueID><ISSNLinking>0347-9994</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004338">Drug Combinations</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007773">Lactates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012464">Saliva, Artificial</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C034179">saliment</NameOfSubstance></Chemical><Chemical><RegistryNumber>25X51I8RD4</RegistryNumber><NameOfSubstance UI="D009536">Niacinamide</NameOfSubstance></Chemical><Chemical><RegistryNumber>33X04XA5AT</RegistryNumber><NameOfSubstance UI="D019344">Lactic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>506T60A25R</RegistryNumber><NameOfSubstance UI="D013012">Sorbitol</NameOfSubstance></Chemical><Chemical><RegistryNumber>K679OBS311</RegistryNumber><NameOfSubstance UI="D002266">Carboxymethylcellulose Sodium</NameOfSubstance></Chemical><Chemical><RegistryNumber>PDC6A3C0OX</RegistryNumber><NameOfSubstance UI="D005990">Glycerol</NameOfSubstance></Chemical><Chemical><RegistryNumber>PQ6CK8PD0R</RegistryNumber><NameOfSubstance UI="D001205">Ascorbic Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001205" MajorTopicYN="N">Ascorbic Acid</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002266" MajorTopicYN="N">Carboxymethylcellulose Sodium</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004338" MajorTopicYN="N">Drug Combinations</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005990" MajorTopicYN="N">Glycerol</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007773" MajorTopicYN="N">Lactates</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019344" MajorTopicYN="N">Lactic Acid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009536" MajorTopicYN="N">Niacinamide</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012464" MajorTopicYN="N">Saliva, Artificial</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012636" MajorTopicYN="N">Secretory Rate</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013012" MajorTopicYN="N">Sorbitol</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014987" MajorTopicYN="N">Xerostomia</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1990</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1990</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1990</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">2147787</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Suède</li></country></list><tree><noCountry><name sortKey="Axell, T" sort="Axell, T" uniqKey="Axell T" first="T" last="Axéll">T. Axéll</name><name sortKey="Birkhed, D" sort="Birkhed, D" uniqKey="Birkhed D" first="D" last="Birkhed">D. Birkhed</name></noCountry><country name="Suède"><noRegion><name sortKey="Bjornstrom, M" sort="Bjornstrom, M" uniqKey="Bjornstrom M" first="M" last="Björnström">M. Björnström</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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